In this video Doctor Andrea Furlan explains why is Vitamin B12 so important, and how to diagnose its deficiency. The talks about megaloblastic anemia, pernicious anemia and microcytic anemia. She also talks about the blood tests and normal ranges. She explains how to obtain Vitamin B12 from diet and supplementation, including oral, sublingual and intra-muscular injections.

00:00 Introduction
00:55 Why is Vitamin B12 important
01:12 Normal blood test
01:23 Anemia
02:13 Homocysteine test
02:33 Recommended daily intake
02:54 Dietary sources
03:19 Malabsorption
03:35 Pernicious anemia
04:20 Pain
04:54 Severe deficiency
05:17 Interaction with other medications

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=============================================
ALERT: This video is not intended to replace medical
advice. If you think you have a condition that is
causing you pain, please consult with your doctor
to get a diagnosis and a treatment plan for you.
The intent of this video is only for educational
purposes.
=============================================
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Vitamin B12 deficiency can occur in all kinds of individuals. It may be of particular concern if you are following a vegan or vegetarian diet, or taking medications that reduce your absorption ability of vitamins. This video looks at what exactly a vitamin B12 deficiency can lead to and the ways in which you can obtain vitamin B12 through your diet or by taking B12 supplements.

This video was created by Demystifying Medicine students Dhruvika Joshi, Prabhjot Khabra, Minahil Jabeen and Vanessa Lombardo.

Copyright McMaster University 2017

References:

1. Bruins Slot, W., Merkus, F. W., Deventer, S. J. H. V., & Tytgat, G. N. (1997). Normalization of plasma vitamin B12 concentration by intranasal hydroxocobalamin in vitamin B12-deficient patients. Gastroenterology, 113, 430-433.

2. Daily Intake. (2017). Canadian Food Inspection Agency. Retrieved 30 October 2017, from http://www.inspection.gc.ca.libaccess.lib.mcmaster.ca/food/labelling/food-labelling-for-industry/nutrition-labelling/information-within-the-nutrition-facts-table/eng/1389198568400/1389198597278?chap=6

3. Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B b6 s, folate, vitamin B b12 s, pantothenic acid, biotin, and choline. (1998) (pp. 306-356). Washington, D.C.

4. Ermens, A., Vlasveld, L., & Lindemans, J. (2003). Significance of elevated cobalamin (vitamin B12) levels in blood. Clinical Biochemistry,36(8), 585-590. doi:10.1016/j.clinbiochem.2003.08.004

5. Ganeson, S., Thanawala, N., & Hussain, N. (2013). Vitamin B12 deficiency: a treatable cause of developmental delay in infancy. J Paediatric Child Health, 49(4): E348-349. doi: 10.1111/jpc.12158

6. Gropper SS, Smith JL, Groff JL. Advanced Nutrition and Human Metabolism: Fourth Edition. Boston, MA: Wadsworth (2004).

7. Hashim, O. H., & Adnan, N. A. (1994). Coenzyme, cofactor and prosthetic group — Ambiguous biochemical jargon. Biochemical Education,22(2), 93-94. doi:10.1016/0307-4412(94)90088-4

8. Hvas, A., & Nexo, E. (2006). Diagnosis and treatment of vitamin B12 deficiency. An update. Haematologica, 91(11), 1506-1512.

9. Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. (1998). Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline. National Academies Press (US).

10. Kwong, J. C., Carr, D., Dhalla, I. A., Tom-Kun, D., & Upshur, R. E. (2005). Oral vitamin B 12 therapy in the primary care setting: a qualitative and quantitative study of patient perspectives. BMC family practice, 6(1), 8.

11. . Langan, R. C., & Goodbred, A. J. (2017). Vitamin B 12 Deficiency: Recognition and Management. American Family Physician, 96(6).

12.. Miller, A., Korem, M., Almog, R., & Galboiz, Y. (2005). Vitamin B12, demyelination, remyelination and repair in multiple sclerosis. Journal of the Neurological Sciences,233(1-2), 93-97. doi:10.1016/j.jns.2005.03.009

13. Møllehave, L. T., Skaaby, T., Simonsen, K. S., Thuesen, B. H., Mortensen, E. L., Sandholt, C. H., … & Linneberg, A. (2017). Association studies of genetic scores of serum vitamin B12 and folate levels with symptoms of depression and anxiety in two danish population studies. European Journal of Clinical Nutrition, 71(9), 1054-1060.

14. National Heart, Lung, and Blood Institute (2011). What are the signs and symptoms of pernicious anemia? Retrieved from https://www.nhlbi.nih.gov/health/health-topics/topics/prnanmia/signs

15. Niculescu, M., & Zeisel, S. (2002). Diet, Methyl Donors and DNA Methylation: Interactions between Dietary Folate, Methionine and Choline. The Journal of Nutrition,132, 2333-2335.

16. Oh, R., & Brown, D. (2003). Vitamin B12 Deficiency. American Family Physician, 67(5), 979-986. Retrieved from http://www.aafp.org.libaccess.lib.mcmaster.ca/afp/2003/0301/p979.html

17. Osimani, A., Berger, A., Friedman, J., Porat-Katz, B. S., & Abarbanel, J. M. (2005). Neuropsychology of vitamin B₁₂ deficiency in elderly dementia patients and control subjects. Journal of geriatric psychiatry and neurology, 18(1), 33-38.

18. Vogiatzoglou, A., Smith, A. D., Nurk, E., Berstad, P., Drevon, C. A., Ueland, P. M., … & Refsum, H. (2009). Dietary sources of vitamin B-12 and their association with plasma vitamin B-12 concentrations in the general population: the Hordaland Homocysteine Study. The American journal of clinical nutrition, 89(4), 1078-1087.

19. Whitney, E., Rolfes, S., Hammond, G., & Piche, L. (2011). Understanding Nutrition (1st ed., pp. 332-334). Toronto: Nelson Education Ltd.

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Three drug-free remedies for knee pain you may not have heard of.

1. Pulsed electromagnetic frequency (worn)
2. Collagen protein (ingested)
3. Cetylated fatty acid (topical)

Knee pain is one of the most common pains in the body. It can occur from injury, post-surgically, or with repeated stress.

Common knee conditions are sprained ligament, meniscus or cartilage damage, tendonitis, bursitis, or wear and tear related to arthritis. Some people can develop knee pain caused by an irritated nerve in the back. Symptoms can include pain, swelling, stiffness, clicking, and popping. 700,000 meniscus surgeries are performed per year despite 3 randomized controlled trials showing no benefit vs sham surgery or PT. A similar number of knee replacements are performed each year in the U.S. One third of knee replacement patients continue to have pain and one in five is dissatisfied with the results.

The three drug free remedies discussed are:

1. Pulsed electromagnetic frequency
Actipatch- https://www.ncbi.nlm.nih.gov/pubmed/26235410, https://www.ncbi.nlm.nih.gov/pubmed/31140929, LBP https://www.ncbi.nlm.nih.gov/pubmed/27910725
https://www.ncbi.nlm.nih.gov/pubmed/30552258
https://www.ncbi.nlm.nih.gov/pubmed/22504115
https://www.ncbi.nlm.nih.gov/pubmed/26705327
Low levels of electromagnetic radiation, charge the mitochondria, increase cellular energy, reduce inflammatory chemicals.
PEMF could alleviate pain and improve physical function for patients with knee and hand OA

2. Collagen
https://www.ncbi.nlm.nih.gov/pubmed/18416885, https://www.ncbi.nlm.nih.gov/pubmed/17076983
https://www.ncbi.nlm.nih.gov/pubmed/26267777
https://www.ncbi.nlm.nih.gov/pubmed/22500661
Collagen peptides
Hydrolyzed collagen peptides
Source from bones, hide, eggshell membrane, fish collagen
10g-12g/day in coffee, water, or smoothies

3. Cetylated fatty acid cream
https://www.ncbi.nlm.nih.gov/pubmed/15903393,
https://www.ncbi.nlm.nih.gov/pubmed/15705022
https://www.ncbi.nlm.nih.gov/pubmed/30874246
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409167/
`Reduced pro-inflammatory cytokine levels, changes in membrane fluidity and signal transduction pathways reducing the proteoglycan degrading enzyme activity, and release of leukotriene B4 from neutrophils have been hypothesized.
-it can be safely prescribed as self- and on-demand treatment.
-In conclusion, the administration of topical CFA may mitigate the most common symptoms in knee OA.
-Findings suggest that topical CFA is effective in all knee OA patients with slightly higher evidence for those with advanced disease.
Dose; apply twice a day, 1-2 mos

If not of these help after 1-2 months then it may not be the treatment for you.

Additional resources:
Knee meniscus: https://regenexx.com/search/knee+meniscus/
Knee replacement: https://regenexx.com/search/knee+replacement/
Knee ACL: https://regenexx.com/search/knee+ACL/

If you would like a non-surgical medical intervention that uses your own cells, please see Regenexx.com
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Earn CME for related activities: https://www.naccme.com

In this presentation from the 2017 Mastering Clinical Challenges and Emerging Therapies in IBD, held July 22, 2017 in Chicago, Illinois, Dr. Reem Jan discusses the rheumatologist’s approach to the management of joint pain in patients with inflammatory bowel disease (IBD).

© 2017 Imedex, LLC.
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This type of cancer grows in the cartilage cells, the connective tissue, in the body. Chondrosarcoma is typically found in the femur, arm, pelvis, knee and spine. Gregory Domson, MD, explains this bone cancer and the treatment options.

For more information: https://uvahealth.com/services/bone-cancer/chondrosarcoma

Chondrosarcoma is a malignancy. It’s a type of cancer that arises from cartilage cells. So, cartilage is really that kind of smooth surface on the end of your bones that helps with gliding of the joints.

Chondrosarcoma, like most bone cancers, starts with bone pain or a mass. The treatment options for chondrosarcoma are usually surgery alone. Cartilage tumors don’t respond as well to radiation treatment and chemotherapy, and so typically surgery is the standard of care.

Surgery for chondrosarcoma can be radical surgery, like an amputation. It can be limb salvage surgery, where we resect a portion of the bone and reconstruct the bone. Also, it can be less invasive surgery where we scrape out the tumor and reconstruct the bone. Not many surgeons are familiar or very comfortable doing resection of chondrosarcoma and reconstruction once the tumor is out. And so often times they go to a tertiary care center to seek a musculoskeletal oncologist, like myself here at UVA.
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What are the benefits of Vitamin B? What are the symptoms of Vitamin B deficiency? What are Vitamin B rich foods? Are there any easy sources of Vitamin B complex? What are the types of Vitamin B? Who is prone to Vitamin B deficiency? Dr Rajesh Bhardwaj, a senior ENT specialist, tells us all about Vitamin B and its supplementation.

Video Breakdown:

0:33 What is Vitamin B

0:55 Importance of Vitamin B

1:45 Vitamin B Deficiency

2:16 Prone to Vitamin B Deficiency

2:34 Sources of Vitamin B

3:10 Vitamin B Supplementation

#vitaminbsources #vitaminbdeficiency #vitaminbcomplex

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Video Transcript:

Introduction
Sometimes, certain people may be deficient in Vitamin B. There are some signs that are
indicative of a deficiency of Vitamin B complex. A simple blood test is done to determine your
serum B complex levels and that will tell you whether you are deficient and if you're deficient
you can take supplementation!

Understanding Vitamin B
Vitamin B Complex is a large group of vitamins – Vitamin B1, B2, B3, B5, B6, B7, B9 and B12.
They are also called by their individual names Thiamin, Riboflavin, Niacin, Pantothenic Acid,
Pyridoxine, Biotin, Folic Acid and Cobalamin.

Importance of Vitamin B
They are all important for bodily functions. They are the building blocks of the human body and
are critical for the human body function. They are responsible for cellular metabolism,
maintaining mental activities and energy levels. Vitamin B complex helps build up red blood
cells or hemoglobin, enables us to have good vision, maintains good cellular function, and are
responsible for neural and muscular functions. They create and help us to have a good appetite.
They are responsible for heart function. Very importantly, pregnant women need a sufficient
amount of Vitamin B Complex for the fetus to develop well, without defects.

Signs of deficiency
These are skin rashes, cracks around the mouth like dryness and cracking scaly lesions on the
lips, swollen tongue, fatigue, weakness, anaemia, irritability or depression, sometimes mental
confusion, Nausea, diarrhea and abdominal cramps. These are some of the common
symptoms of vitamin B complex deficiency.

People who are prone to Vitamin B deficiency
People who are more at risk of developing vitamin B complex deficiency are those who have
celiac disease, ulcerative colitis, chronic alcohol users and sometimes, people with rheumatoid
arthritis and Crohn's disease and HIV. People with these diseases may not be able to absorb
enough vitamin B complex from the intestine and they suffer from deficiencies.

Sources of Vitamin B
Vitamin B12 is readily available to us in a variety of food forms from milk, cheese, eggs and
meat. It is also available to us in green leafy vegetables like spinach. You can also get it from
cereals like wheat germ. It is readily available in nutritional yeast, nuts and seeds, which have
plenty of vitamin B complex. Also, fruits such as citrus fruits, banana and watermelon contain
good quantities of Vitamin B complex.

Do we need vitamin B complex supplementation?
As we have seen most of us get it from our daily food and we do not need supplementation.
There are certain situations where you might need to supplement particularly those who suffer
from chronic alcoholism. Additionally, pregnant ladies may need extra folic acid so that they can
have healthy babies. Those who eat a purely vegetarian diet can sometimes be nutritionally
deficient and sometimes they may be deficient in Vitamin B.
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Chronic joint pain affects millions of people of people across the world every year. Thousands of patients routinely seek medical attention for joint pain, and it is one of the leading causes of disability.

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To give you an estimate of the disease, in 2002, about 10.5 million people in the United States said they experienced severe joint pain, but by 2014 that number had jumped to 14.6 million, said researchers from the U.S. Center for Disease Control and Prevention. Severe Joint pain can limit a person’s ability to perform basic functions and seriously compromise their quality of life.

Luckily with strict precautions, good exercise, proper diet and supplementation joint pain can be managed. In this video we discuss five of the best foods that you should include in your diet if you are suffering from joint pain, and also the science behind it

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In this video we will provide a basic definition of barometric pressure, discuss how this may increase pain in patients with osteoarthritis, and provide recommendations on how to help manage the pain.

Can you tell when it’s going to rain? In our Ask the Expert video series, we discuss sensitivity to pressure changes for individuals living with #hydrocephalus.
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It’s the common health condition that’s notoriously difficult to spot. But with symptoms including fatigue, headaches, pins and needles, and even depression – could you have missed the signs of a B12 deficiency? After waiting over a year for a diagnosis, entrepreneur Carrie-Ann Kay joins us alongside Dr Chris.
Broadcast on: 21/05/19

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This video is about Plan B
How to use safely and important things to know.

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Disclaimer :
*This is not direct medical advice. Consult a physician prior to self treating any medical condition.
*This video is not sponsored
*As an Amazon Associate I earn from qualifying purchases.
*I get commissions for purchases made through links in this post.
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The information provided on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images and information, contained on or available through this site is for general information purposes only. The content creator makes no representation and assumes no responsibility for the accuracy of information contained on or available on this site and such information is subject to change without notice. You are encouraged to confirm any information obtained from or through this site with other sources, and review all information regarding any medical condition or treatment with your physician.

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Top 5 Signs Your Shoulder, Hip, or Knee Pain Is NOT Arthritis

Bob and Brad discuss signs that your pain is not arthritis for your shoulder, hip, or knee.

This Week’s Giveaway:
We are giving away a suite of Renpho products!

Included in the suite is a a foot massager, chair massager, shoulder massager, and three handheld massagers.

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Each of these products and more will be on sale between Black Friday and Cyber Monday, and Bob & Brad Fans will get an additional 5% off with the following discount code: BOBBF888

Links to purchase:
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Pain, swelling and stiffness in your joints. All are symptoms of rheumatoid arthritis. But because these symptoms come and go, the condition can sometimes be tricky to diagnose. And it’s important to get the right diagnosis because starting treatment early can make a difference.

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